| alexrown's Forum Info |
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| Additional Info About alexrown |
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Allopurinol is a synthetic compound primarily used in the management of gout and certain types of kidney stones by inhibiting the enzyme xanthine oxidase, which plays a crucial role in uric acid production. The synthesis of allopurinol begins with the condensation of diethyl malonate and urea to form a substituted pyrimidine intermediate. This intermediate undergoes further reactions, including cyclization and hydrolysis, leading to the formation of 5-hydroxy-1H-pyrazole-4-carboxamide. A subsequent reaction with 4-oxo-2-imidazolidinone gives rise to allopurinol. This multi-step synthesis involves various chemical transformations and requires careful control of reaction conditions to yield high purity and efficiency. The final product is crystallized to obtain allopurinol in a form suitable for pharmaceutical applications, providing significant benefits in conditions characterized by elevated uric acid levels. |
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